Kawasaki disease causes swelling of the heart's blood vessels and mainly affects children under the age of 5, according to the U.K.'s NHS. Individuals may print one hard copy of an individual disease for personal use, provided that content is unmodified and includes NORD’s copyright. In addition, a characteristic red skin rash develops. Although she has recovered medically, she appears to have some behavioral and developmental problems. Harrison’s Principles of Internal Medicine, 14th Ed. Estimates indicate that at least 3,000 cases of Kawasaki disease are diagnosed each year in the United States. NORD is a registered 501(c)(3) charity organization. You may want to review these resources with a medical professional. Outcome of coronary artery aneurysms after Kawasaki disease. 1994;89:916-22. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. In addition, in some cases, heart involvement may include inflammation of the membranous sac surrounding the heart (pericarditis), leakage of certain heart valves (aortic or mitral valve insufficiency), or other abnormalities. Children with Kawasaki disease usually improve significantly within 24 hours of treatment with, Conditions with similar signs and symptoms from Orphanet. Patients must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure or treatment of a condition or disorder. rare disease research! Visit the group’s website or contact them to learn about the services they offer. Choi IH, et al. Symptoms may include fever, cough, sore throat, runny nose, redness of the eyes (conjunctivitis), and increased sensitivity to light (photophobia). J Thorac Cardiovasc Surg. Lancet. For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office: For information about clinical trials sponsored by private sources, contact: Behrman RE, ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:2360-63. Without early diagnosis and appropriate treatment, life-threatening complications may result. Additional research is needed. Kawasaki disease is an auto-immune disease that results in a fever and mainly affects children under 5 years of age. Beers MH, et al., eds. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments. Get the latest public health information from CDC: https://www.coronavirus.gov (link is external) But the syndrome linked to COVID-19 seems to affect older children, too. Gorbach SL, et al., eds. First reported in Japanese children in the 1960s, the disease is now recognized worldwide and occurs in individuals in all racial and ethnic groups. A rare childhood illness, Kawasaki disease is a multisystem disorder involving vasculitis—inflammation of the inner lining of the blood vessels—that can harm the coronary arteries. If we don't have a program for you now, please continue to check back with us. The treatment of Kawasaki syndrome with intravenous gamma globulin. These resources provide more information about this condition or associated symptoms. If you can’t find a specialist in your local area, try contacting national or international specialists. The Food and Drug Administration (FDA) has approved the following IGIV products (immune globulin intravenous [human]) for the treatment of Kawasaki disease: Gammagard S/D, manufactured by Baxter Healthcare; Venoglobulin-S, manufactured by Alpha Therapeutic; Venoglobulin-I, manufactured by Alpha Therapeutic; and Iveegam, manufactured by Baxter Healthcare. However, Kawasaki disease appears to affect Asian children most frequently. Experts indicate that children with Kawasaki disease should be treated by or in consultation with pediatricians who specialize in the diagnosis and treatment of heart disorders (pediatric cardiologists). 1995;172:558-61. December 1, 2020, Rare Diseases Are Not Rare - Gallery of Creative Work Raises Awareness of Rare Diseases http://www.nlm.nih.gov/medlineplus/ency/article/000989.htm, http://www.nhlbi.nih.gov/health/health-topics/topics/kd/, http://www.uptodate.com/contents/kawasaki-disease-initial-treatment-and-prognosis, http://ghr.nlm.nih.gov/condition/kawasaki-disease, https://www.uptodate.com/contents/kawasaki-disease-epidemiology-and-etiology?source=see_link, http://www.heart.org/idc/groups/heart-public/@wcm/@hcm/documents/downloadable/ucm_300320.pdf. 3rd ed. Treatment is started as soon as possible after diagnosis and may include high-dose intravenous immune globulin (IGIV) and high-dose aspirin therapy. A multicenter cooperative study. bacterial toxic shock syndrome, leptospirosis, adenophlegmon), viral infections (i.e. In rare cases, coronary artery bypass surgery or heart transplantation may be recommended for individuals with severe heart involvement. Leung DY, et al., Toxic shock syndrome toxin-secreting staphylococcus aureus in Kawasaki syndrome. Electrocardiograms (EKGs) are often performed along with echocardiograms. Recent evidence by Yale University investigators (2005) suggests that a newly discovered coronavirus may have a role in Kawasaki disease. J Infect Dis. It involves inflammation of the blood vessels, and it affects the arteries. Report from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young. Research helps us better understand diseases and can lead to advances in diagnosis and treatment. Hum Immunol. We want to hear from you. Cohen Tervaert JW, et al. Kawasaki disease is a rare illness that usually affects small children. Comparisons may be useful for a differential diagnosis: Measles is a highly contagious viral disease occurring primarily in children. 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